Macrolide lactams
Medchemexpress LLC D-alanine, N-(1-oxoheptyl)-D-γ-glutamyl-(6R)-6-carboxy-L-lysyl- | 79335-75-4 | 99.9% | 502.56 | C22H38N4O9 | 1mg
FK-565 is a nucleotide oligomerization domain-1 (NOD1) ligand FK-565 induces murine model with arteritis[1]
Medchemexpress LLC LL-37 FK-13 TFA | 98.6% | 1719.09 | 1 MG
LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). It is an antimicrobial agent that inhibits *Trichomonas vaginalis*. LL-37 FK-13 TFA shows minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts.
- Antimicrobial agent
- Inhibits *Trichomonas vaginalis*
- Minimal hemolytic effects on human erythrocytes
- Low cytotoxicity to human fibroblasts
Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 100mg
Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies
Abcam FK506 (Tacrolimus), Immunosuppressant, 50MG
MW 804 Da, Purity >98%. Immunosuppressant. Complexes with FKBP-12 to inhibit calcineurin. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam FK506 (Tacrolimus), Immunosuppressant, 10MG
MW 804 Da, Purity >98%. Immunosuppressant. Complexes with FKBP-12 to inhibit calcineurin. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Tacrolimus monohydrate | 109581-93-3 | 99.9% | 822.03 | 200 MG
Tacrolimus monohydrate is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex. This complex inhibits calcineurin phosphatase, which in turn inhibits T-lymphocyte signal transduction and IL-2 transcription. It exhibits immunosuppressive properties and is for research use only.
- Binds to FK506 binding protein (FKBP) to form a complex
- Inhibits calcineurin phosphatase
- Inhibits T-lymphocyte signal transduction and IL-2 transcription
- Exhibits immunosuppressive properties
- Inhibits calcium-dependent events such as IL-2 gene transcription, NO synthase activation, cell degranulation, and apoptosis
- Potentiates glucocorticoid and progesterone actions
- May enhance TGFβ-1 gene expression
- Inhibits T cell proliferation
Research Products International Corp FK-506, 25 MG
Substance Name: [Tacrolimus] [Fujimycin]
CAS Number: 104987-11-3
Molecular Formula: C44H69NO12
Molecular Weight: 804.0
Sigma Aldrich Fine Chemicals Biosciences 2 Propanol System Suitabil
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
Medchemexpress LLC Tacrolimus (FK506) | 104987-11-3 | MFCD00869853 | 99.6% | 803.48 Da | C44H69NO12 | 5 MG
Tacrolimus (FK506) analytical standard intended for research and analytical applications. Tacrolimus is a macrolide immunosuppressant that binds FK506 binding protein and inhibits calcineurin, affecting T-lymphocyte signal transduction. This reference material is supplied for assay calibration, method development, and quality control in analytical workflows.
- High-purity reference material (99.6%).
- Intended for analytical and research use, including assay calibration and method development.
- Available in small mass quantities suitable for analytical workflows (e.g., 5 mg).
- Provides a stable, characterized standard for quality control.
- Supplied with documentation for purity and identity.
Sigma Aldrich Fine Chemicals Biosciences FK-506 monohydrate >=98% (HPLC) | 109581-93-3 | MFCD11045918 | 5MG
FK-506 monohydrate >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 | 5MG
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.
AdipoGen Ascomycin high purity
Chemical. CAS 104987-12-4. Formula C43H69NO12. MW 792. Isolated from Streptomyces sp. Macrolide antibiotic. Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin protein phosphatase 2B PP2B. Suppresses the production of T helper type 1 Th1 interferon and IL-2 and Th2 IL-4 and IL-10 cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant antiepileptic.